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BEGIN:VEVENT
UID:20251101T143620EDT-5747JIagoL@132.216.98.100
DTSTAMP:20251101T183620Z
DESCRIPTION:\nGrâce à la générosité des fiducies Killam\, Le Neuro convoque
  lors d’une série de séminaires des conférenciers d’exception dont les tra
 vaux passionnent ses chercheurs et ceux de l’Université ºÚÁÏÍø. \n\n\nPour
  participer en personne\, inscrivez-vous ici\n\nPour visionner la diffusio
 n sur Vimeo\, cliquez sur le lien suivant\n\n\nIain Clark\n\nProfesseur ad
 joint\, bio-ingénierie\, UC Berkeley\, États-Unis\n\nHôte: jo.stratton [at
 ] mcgill.ca (Jo Anne Stratton)\n\nAbstract: Central nervous system (CNS)-r
 esident astrocytes and microglia interact to regulate pro-inflammatory pro
 grams that drive neurodegenerative diseases\, but the pathways and molecul
 es involved are largely unknown. Understanding the language of inflammatio
 n is a central question in the field of Neuroimmunology and may guide new 
 therapeutic approaches for multiple sclerosis (MS) and other neurologic di
 seases. Interactions between CNS-resident cells are highly heterogeneous\;
  astrocytes and microglia nourish and protect neurons\, while inflammatory
  subsets drive demyelination and neurodegeneration in neurologic diseases.
  We recently developed two novel approaches to study astrocyte-microglia i
 nteractions at the single-cell level during inflammation: 1) an in vivo ba
 rcoding-based strategy that analyzes the transcriptomes and connections be
 tween individual cells\, and 2) a droplet-based platform for genome-wide\,
  unbiased CRISPR/Cas9 screening of genes that mediate cell crosstalk. In t
 his seminar\, I will discuss the development of these technologies and the
 ir application to study astrocyte-microglia signaling in experimental auto
 immune encephalomyelitis (EAE)\, a preclinical mouse model of MS.\n
DTSTART:20240220T210000Z
DTEND:20240220T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Microfluidic tools for studying cell-cell in
 teractions 
URL:/neuro/fr/channels/event/killam-seminar-series-mic
 rofluidic-tools-studying-cell-cell-interactions-353656
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