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UID:20251108T063207EST-7679Apljmg@132.216.98.100
DTSTAMP:20251108T113207Z
DESCRIPTION:Xavier Roucou will present\, “Towards a more authentic vision o
 f the (multi)coding potential of RNA'.\n\nRegistration available here.\n\n
 Speaker: Xavier Roucou\, PhD\n	Professor and Department Chair\, Department 
 of Biochemistry and Functional Genomics\, Université de Sherbrooke\n	Canada
  Research Chair in Functional Proteomics and Discovery of Novel Proteins\n
 \nAbstract: Ten of thousands of open reading frames (ORFs) are hidden with
 in transcripts. They have eluded annotations because they are either small
  or within unsuspected locations. These are named alternative ORFs (altORF
 s) or small ORFs and have recently been highlighted by innovative proteoge
 nomic approaches\, such as our OpenProt resource\, revealing their existen
 ce and implications in biological functions. Due to the absence of altORFs
  from annotations\, pathogenic mutations within these are being ignored. I
  will discuss our latest progress on the re-analysis of large-scale proteo
 mics datasets to improve our knowledge of proteomic diversity\, and the fu
 nctional characterization of a second protein coded by the FUS gene. Final
 ly\, I will explain the need to map the coding potential of the transcript
 ome using artificial intelligence rather than with conventional annotation
 s that do not capture the full translational activity of ribosomes.\n\n\nS
 upported by the generosity of the Killam Trusts \, The Neuro’s Killam Semi
 nar series hosts outstanding guest speakers whose research is of interest 
 to the scientific community at The Neuro and ºÚÁÏÍø.\n
DTSTART:20220118T210000Z
DTEND:20220118T220000Z
SUMMARY:Killam Seminar Series presents 'Towards a More Authentic Vision of 
 the (multi)Coding Potential of RNA'
URL:/neuro/channels/event/killam-seminar-series-presen
 ts-towards-more-authentic-vision-multicoding-potential-rna-335992
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