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DESCRIPTION:*Emergence and control of spatiotemporal sequences of neuronal 
 activity in biological neuronal networks*\n\nArvind Kumar\, KTH Royal Inst
 itute of Technology\n	Tuesday September 15\, 12-1pm\n	Zoom Link: https://us0
 2web.zoom.us/j/85119455414?pwd=eVhyT3ZtdDVUdkZiOHM1TDF1MFdMUT09.\n\nAbstra
 ct: Ordered sequences of actions are the key to any meaningful behavior. T
 his also implies that the task-related neuronal spiking activity in the re
 levant brain regions must also be ordered in temporal activity sequences. 
 This idea was conceptualized by Sherrington in his enchanted loom analogy 
 and neutralized by Donald Hebb as phase sequences.\n\nIn the last decade t
 emporal sequences of neuronal activity have been observed in many sensory\
 , motor and cognitive tasks. Mechanisms underlying the emergence of such s
 equential activity are poorly understood. Existing models are biologically
  untenable because they either require manual embedding of a feedforward n
 etwork within a random network or supervised learning to train the connect
 ivity of a network to generate sequences. Could there be some other more g
 eneric and biologically plausible mechanisms that intrinsically render the
  network to generate sequential activity?\n\nWe found that when (1) neuron
 s project a small fraction of their outputs to a preferential direction an
 d (2) the preferred directions of neighboring neurons are similar\, the ne
 twork can generate temporal sequences without learning. This generative ru
 le results in ‘spatial correlated anisotropic connectivity’. Such connecti
 vity can arise when neighbouring neurons have similar morphologies or but 
 also when neurons form long-range patchy connections.\n\nFinally\, I will 
 argue that spatially patchy patterns of neuromodulator release is a simple
  and natural way to generate ‘correlated spatial anisotropic connectivity.
  This way neuromodulators can not only allow for the formation of temporal
  sequences but also provide a biological plausible way to dynamical contro
 l the arrangement of sequences. Thus\, spatial structure of the connectivi
 ty or neuromodulators can form the basis of temporal structure of neuronal
  activity or the phase sequences of Hebb.\n
DTSTART:20200915T160000Z
DTEND:20200915T170000Z
SUMMARY:QLS Seminar Series -Arvind Kumar
URL:/qls/channels/event/qls-seminar-series-arvind-kuma
 r-324216
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