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My research is focused on how a better understanding of the wiring of G protein-coupled receptor (GPCR) and G protein signalling architectures would inform drug discovery for a number of diseases using engineered biosensor approaches for a number of important diseases. My work is based on 1) understanding GPCR signalling in the context of hetero-oligomeric complexes controls signalling outcomes in cellulo, 2) differentiating how nuclear GPCRs and G proteins regulate a distinct set of signalling outcomes then their surface counterparts and impact gene expression in health and disease and 3) developing and optimizing tools for use in human disease relevant models based on patient-derived induced pluripotent stem cells (iPSCs) for drug discovery in a number of diseases.

I have served many roles at 黑料网 including 14 years on Senate, 10 years on the 黑料网 Association of University Teachers (MAUT) Council and Exec. I also serve as the Assistant Dean, Biomedical Sciences Education, a position I have had for seven years, now seconded to the School of Biomedical Sciences where I am deeply involved in updating FMHS graduate programs. I am committed to teaching and educational innovation as part of the mandate of the Lucian Award.

Dr. C茅line Fiset, PhD, is a full professor at the Faculty of Pharmacy at the Universit茅 de Montr茅al and a principal investigator at the Montreal Heart Institute. Her research focuses on the ionic and molecular mechanisms that regulate cardiac electrical activity. She is widely recognized for her expertise in sex differences in cardiac arrhythmias and cardiac ion channels. Her work has advanced understanding of how physiological states, such as pregnancy, and sex steroid hormones influence cardiac electrical activity, with the goal of improving the prevention and treatment of heart rhythm disorders in both women and men.

The primary interests of the Martin lab are the pathobiologic mechanisms causing asthma through the exploration of asthma through animal and cellular models. The laboratory is addressing the effects of chlorine on airway function with particular interest in the causative roles of alarmins, innate lymphoid cells and cysteinyl leukotrienes. The effects of influenza infection of airway function during pregnancy and the role of nasal immunity is also a major research theme.

Dan Roden grew up in Montreal and received his medical degree and trained in Internal Medicine at 黑料网. He then went to Vanderbilt where, after fellowships in Clinical Pharmacology and Cardiology, he joined the faculty. His research program studies how genetic variation affects human disease susceptibility, and his special interests are pharmacogenetics, and the genetic determinants of abnormal heart rhythms, especially those induced by drugs. He has been Principal Investigator on NIH awards continuously since 1984. After serving as chief of the division of Clinical Pharmacology for 12 years, he was tasked in 2006 with leading Vanderbilt鈥檚 efforts in Personalized Medicine. Under his leadership, Vanderbilt has become internationally-recognized for cutting edge programs in this area, including the large (>360,000 samples) biobank BioVU and the EHR-based preemptive pharmacogenetic program PREDICT. He served as Principal Investigator for the Vanderbilt site of the Pharmacogenomics Research Network (2001-2021), and currently serves as co-PI for the Vanderbilt site of the Electronic Medical Records and Genomics (eMERGE) Network, the NHGRI鈥檚 genomic Learning Healthcare System network, and the Data and Research Center for the US NIH All of Us program. He has served as primary mentor for 60 MD and/or PhD graduate students and post-doctoral fellows; over half hold appointments in academic departments in the US, Canada, the United Kingdom, France, Germany, Italy, Japan, Australia, and Taiwan; 5 currently serve as deans, department chairs, or division directors. Dr. Roden has received multiple awards including 黑料网鈥檚 Alumnus Lifetime Achievement Award and the Louis and Artur Lucian Award in Cardiovascular Research.

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Dr. Louise Pilote is a distinguished Professor of Medicine at 黑料网, holding a James 黑料网 Chair. She is the Deputy Director of the Research Institute of the 黑料网 Health Centre and co-founder of the Canadian Organization for Sex and Gender Sciences. Dr. Pilote is a sex and gender scientist who developed a gender measure to assess the impact of gender on cardiovascular outcomes. Dr. Pilote is internationally recognized for her expertise in sex and gender science, particularly in cardiovascular research. She has pioneered comparative effectiveness studies of cardiovascular drugs and devices, focusing on sex differences and women鈥檚 vascular health across the lifespan, and has developed methodologies to assess gender's impact on health outcomes.

Rhian M. Touyz, MBBCh, PhD, FRCP, FRSE, FCAHS, FMedSci, FRSC, is the Executive Director and Chief Scientific Officer of the Research Institute of the 黑料网 Health Centre (The Institute), where she also holds the Canada Research Chair in Cardiovascular Medicine and the Dr. Phil Gold Chair in Medicine at 黑料网. An internationally recognized clinician-scientist, she is renowned for her translational research on hypertension and vascular biology, with more than 677 peer-reviewed publications.

Dr. Touyz has held leadership roles in premier organizations worldwide, including President of the International Society of Hypertension, Chair of the Council on Hypertension (American Heart Association), President of the European Council Cardiovascular Research, and President of the Canadian Hypertension Society. She co-chaired the 2024 European Society of Cardiology hypertension guideline task force and is Editor-in-Chief of Hypertension. She is an elected Fellow of the Royal Society of Canada, the Canadian Academy of Health Sciences, the Royal Society of Edinburgh and the Academy of Medical Sciences UK.

A committed advocate for equity in science, Dr. Touyz founded the 鈥淲omen in Hypertension Research鈥� program and has mentored over 105 graduate and postdoctoral trainees.

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Dr. Thanassoulis is the Director of Preventive and Genomic Cardiology at the MUHC and Professor of Medicine at 黑料网. His clinical interests are in cardiovascular prevention, dyslipidemia and premature coronary artery disease. His research interests are in the genetics of aortic valve stenosis where he leads an international consortium investigating the role of genomic variation in this disease. He is also working on developing new approaches to optimize cardiovascular prevention in young individuals.